ARTIFICIAL LEGS Largest Firm in U.S. THE WINKLEY MINNEAPOLIS, MINN. CONTENTS. The Medical Efficacy of Nosophen and Antinosine in Eye, Ear, Nose and Throat Affections, by James A. Lydston, M.D., Chicago, Illinois A Plea for Psychical Realism, hy James Weir, Jr., M.D., Owensboro, Kentucky The Treatment of Puerperal Phlegmasia Alba Dolens, by T. Mitchell Burns, M.D., Den- Is an Absolute Condemnation of Alcohol Just? by Albert Bernheim, M.D., Paducah, Ky... 12 Is the most satisfactory dusting powder for almost all purposes. It does not cake, never becomes rancid nor "sticky,” resists moisture and does not soil the clothing. este o It can be applied to the nose, throat or other passages without Ichthyol is of undoubted value in many forms of skin disease. In some cases it gives results which no other agent will produce. The objection to its use on account of its odor, etc., are largely overcome in our combination of Compound We shall be pleased to send samples of this or any other combination, together with Pamphlet containing full list of combiuations and uses, on application. 5529 LIBRARY DENVER MEDICAL TIMES VOLUME XIX. JULY, 1899. NUMBER 1. ORIGINAL COMMUNICATIONS. THE MEDICAL EFFICACY OF NOSOPHEN AND ANTINOSINE IN EYE, EAR, NOSE AND THROAT AFFECTIONS. * By JAMES A. LYDSTON, M.D., Ph.G., Chicago, Illinois. So great is the multiplicity of indifferent therapeutical agents thrust upon the medical fraternity at the present time that we should rejoice over the presentation of any chemical agent that is really entitled to a place in our therapeutical armamentarium by virtue of true merit. Among the many pro ducts that have been extolled in recent years as possessing su. perior germicidal and antiseptic qualities are two chemical compounds, viz.., nosophen and antinosine, the first being chemically, as described by Classen and Loeb, tetra iodophnolphthalein, and the latter the sodium salt of the same. Nosophen being a light impalpable yellowish gray, practically odorless, tasteless powder, very stable, requiring a temperature of 220 C. for decomposition, containing 61.7 per cent. of iodine in combination resulting from chemical reaction between iodine and phenolphthalein solutions, characterized by being insoluble in water and acids, soluble with difficulty in alcohol, glacial acetic acid, chloroform and ether, and readily soluble in alkaline solutions, from which it is readily separable at low temperature by carbonic acid-acid in character, containing as it does two hydroxyl groups, it is freely soluble in alkalies, the hydrogen in both hydroxyl groups being replaced by the metal. The sodium salt thus obtained has been isolated and is styled antinosine-this compound, the sodium salt of nosophen, is a dark blue amorphous, odorless, non-toxic, non-irritating * Read before Chicago Medical Society, May 24, 1899. |
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