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COCAINE HYDROCHLORATE.

(MURIATE OF COCAINE.)

-AND

JOJAIME LYDROBROMATI,

PURE IN CRYSTALS.

The Crystalline Form the Best Guarantee of Purity.

The extraordinary demand for the muriate of cocaine has flooded the market with a crude product, hastily prepared, and having no appearance, even under the microscope, of crystalline structure. None of it has been free from a tinge of color, and it produces a solution more or less colored.

Some of the European manufacturers have supplied a pure article, which is not only wbolly free from color, but possesses a distinct crystalline structure. The price of this crystallized article has been held firmly at a higher figure than that of the amorphous salt, which, obviously, does not bear in its form the guarantee of its parity.

Crystallized Muriate of Cocaine. We have been the first among American manufacturers to produce a crystallized muriate of cocaine, and we invite comparison of our product with that of any foreign or home manufacturer.

We find that the crude amorphous salt. with which the market is now largely supplied, yields only 80 to 85 per cent. of its weight of crystals. The remainder consists of a mixture of alkaloidal salts, the most important constituent being apparently a compound closely related to cocaine, and very possibly isomeric with it, but having a much lower fusing point, and assuming the crystalline form with difficulty, if at all. It is clear, therefore, that the colorphous salt is not equal in value to the crystalline, which latter is the only form in which we offer tho salt itself.

Cocaine Eydrobromate vs. Cocaine Muriate. Of all the salts of cocaine the crystallized muriate is that which hithertu has given the most complete satisfaction; it is likely, however, to find a formidable rival in the Crystallized Hydrobromate of Cocaine, which we also manufacture, and to which we desire to call the attention of physicians. Those who have used this salt declare that its effects are more powerful and more promptly produced than those of the muriate..

Wbile, therefore, we would especially commend to our medical friends these crystallized salts of cocaine in substance, we shall be pleased to supply to those who still prefer to use the drug in this form solutions of these salts, whieb are prepared with the greatest care, of the strength stated below.

We offer the following preparations of cocaine, and shall be pleased to furnish on application prices and any desired information regarding their use:

Cocaine Alkaloid (pure in crystals).
Cocaine Citrate, 4 per cent. solution.
Cocaine Hydrobromate (pure in crystals).
Cocaine Muriate (pure in crystals).
Cocaine Muriate, 2 per cent, solution.
Cocaine Muriate, 4 per cent, solution.
Cocaine Oleate containing 5 oct of the alkaloid.

:
Cocaine Salicylate, 4 per cent, solution.

PARKE, DAVIS & CO.,

Manufacturing Chemists,
NEW YORK BRANCH:

DETROIT, MICHIGAN. 60 Maiden Lane & 21 Liberty Street,

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THE DENVER

MEDICAL TIMES

A MONTHLY JOURNAL OF

MEDICAL SURGICAL AND OBSTETRICAL SCIENCE,

Edited by THOMAS H. HAWKINS, M.D.

JULY, 1885.

*

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PUERPERAL FEVER (Abstract).

BY DR. A. J. RUSSELL. Who of us present here to-night can not call to mind a case, after labor seemingly the most satisfactory, which from the second to the fourth day, seldom earlier, sometimes later, was pectedly changed into one of the gravest and most alarming, by a sudden and extreme rise of pulse and temperature, distention of the abdomen, tenderness in one or both illiac regions, cessation, partial or complete, of the lochia, with momentous head symptoms pointing plainly to the oncoming delirium, perhaps of the greatest consequence to the welfare of our patient, who, but a few days ago, full of hope and promise of well-doing, now lies prostrate under a cloud of complications, the septic nature of which is at the present time so intently occupying the careful study and consideration of our most thoughtful and learned physicians ?

Wlio can with such a case, point out, or lay his finger upon the starting place and say, here is the cause, or there resides the source and

*Read before the Arapahoe County Medical Society.

fountain-head of all this trouble? When we take into consideration the greatly altered blood state of the parturient female brought about by the wonderful course or operation of building up within the body of the mother another life, resulting in the physiological increase of fibrin, white corpuscles, and water, with a corresponding decrease of red corpuscles and a high state of nervous excitability and the astonishing amount of absorbtion and excretion which must rapidly go on after delivrey.can we wonder that at times there may be a lost balance between these two latter functions and that the retention within her system of dead or effete material, which should have found a rapid exit through the excretory organs, will set up serious constitutional irritation?

We all know only too well the horrible results of this lost balance between secretion and excretion even in natural fluids, such as that of a joint, the pleura, the tunica vaginalis, or even the pent up menstrual Auid in a virgin uterus, how by their presence, rapid changes are brought about suppuration established and, by the severe impressions thus made upon the blood, we have systemic disturbances of the most alarming kind and life itself destroyed. Can we wonder when we recollect the well known influence of emotions upon secretion and excretion, that our patient may be thus profoundly impressed and that in some cases this alone may be the most conspicious, if not the sole cause of her fever? Or when owing to local or other predisposing conditions, the economy has all it can do to resist the threatened trouble, this disturbance through the nervous centres may be a sufficient exciting cause to disturb the balance and check the excretions for the time entirely. Here then we have as a result a disturbed system, quick pulse, increased temperature, wakeful nights, coated tongue, later on, disturbance of the digestive organs, swollen belly, a scanty and offensive discharge from the womb, and in short a fever, which during the puerperal state, may be, and is, properly diagnosed puerperal fever-puerperal septicemia if you like--but it is one of those cases wherein the patient herself has furnished the toxic element from her own system for the establishment of the malady. Take for illustration an other case, when, owing to severe and prolonged labor, the soft parts from the neck of the uterus down to the vulva have been bruised, lacerated and torn, the mucous tract and the submucous connective tissue contused and perhaps sloughing in patches here and there, we have as a result, a local inflamation with all the products of such inflammatory action, ready to be taken up and carried into a circulation already over burdened and taxed by effete and useless debris. Now to neg. lect this local injury and allow these inflammatory exudates to become pent up in the cavity of the womb and in the vaginal canal and through

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