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The classification of different forms of cancer if properly carried out, might lead to the elimination of some forms which may be found to be due to special parasites (as for example, actinomycosis has been eliminated), and to the separating off of what may be found to be special types, or only seeming cancer. In all investigations of this nature full and detailed histological, chemical, bacterial, or other parasitic investigations must be made and a full history of each case clinically recorded.

The reputed transplantation of cancer into wound margins ought to be specially enquired into, with a view to the important bearing such an occurrence would have on other transplantation experiments. Such transplantation experiments should only be carried out with regard to the special species of animal in which the original growth occurred, and the special tissue in which it seemed to have had its origin. For all experiments of this nature the importance of the assistance of a trained veterinary man is very evident, for it would be. especially necessary to exclude the possibility of previous infection.

A systematic study of the effects of persistent irritation of different epithelial surfaces in different species of animals might be found to have important bearings. In this category possibly the study of "Petroleum cancer" and "Sweeps' cancer" might be placed.

Those engaged in post-mortem examinations should be encouraged to search systematically for, and record all evidence of incipient or undetected malignant disease. Such an investigation might throw much light on the internal conditions, e. g., in the alimentary canal, which in themselves may perhaps lie long dormant, and in the end become malignant, in the same way as other conditions on the surface of the body are known to do.

A comparative study of mitosis and vegetative activity would require to be undertaken. Such an investigation would cover not only mitotic and vegetative activity in embryonic and cancer cells, but also that occurring in the cells of benign tumours, and of tissues which have reverted to an embryonic type in processes of repair, and with consideration of that over-production which is an essential feature of repair.

I would respectively submit that any such scheme as the foregoing can only be provisional, and has been drawn up in full consciousness of the difference between drawing up a scheme on paper and putting the same into practice. I do not claim that this hastily drawn up scheme is adequate to cover the whole field of enquiry. In conclusion I would point out that the investigation must necessarily follow the lines which accumulated experience will dictate.

Edinburgh,

October 24th, 1902.

(Signed)

E. F. BASHFORD.

INDEX.

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Accuracy in dosage, 364.
Accurate statistics, value of, 23.
Acids and alkalies on developing
Echinoderm eggs, effects of, 57.
free organic, 399.
Acinous areas into alveolar, trans-
formation of, 87, 254.

type of growth, 86, 187.
Acquired resistance, 120, 133, 136,
319, 338, 341, 375, 395.
Action of radium, 298.
Active hydrochloric acid, increase in
secretion of, 398, 399.
immunity, 338.

Adaptability and biological altera-
tions of tumour cells during
propagation, 257, 269.

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intestine in fowls, 45.

Adenoma of the liver of mouse, 72.
of the liver, malignant, in
cows, 42.

of the lung in mice, 73, 76, 78,
220.

-, sebaceous, 74, 76.
Adenomata and carcinomata, impos-
sible distinct division between
hæmorrhagic, 124.

of the skin of the frog, mul-
tiple, 47.

Adenomatous areas, association of
keratinised and, 164.

structure of a lymphatic glan-
dular metastasis in hæmor-
rhagic spontaneous tumours, 25,
131.

structure, reversion of alveolar
carcinoma to, 77, 86, 116, 124.
Adrenal tissue, cortical, 48.

tumours in the frog, bilateral,
47.

Age-incidence of carcinoma and sar-

coma, 6.

Age, influence of, 285, 317, 325.
in native races, 14.

Albrecht, E., 108.

Albrecht, H., 199.

Alleged increase of cancer, 8, 16.
Allen, Dr. E. J., 41, 53.
Allen, Dr. M. B., 31.

Alteration of sarcoma cells, progres-
sive biological, 256.

Alternating phases of increased and

diminished energy of growth,
276, 278, 300.

phases in tumour-cells, nature
of, 280.

- phases of keratinised epithelium
with solid carcinomatous, 172.

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Amphiaster, 64.

Amphibian, urodele, 50.

Amphibians, cancer in, 47.

ANALYSIS OF GROWTH OF CANCER, EX-
PERIMENTAL, 284.

of stomach contents, man,
Table XIV., 418, 419.

of stomach contents, mice,
Tables I.-XI. & XIII, 403–419.
of stomach contents, rats,
Table XII., 415.

Anaplasia, 89, 169, 172, 173.
Anatomy and histology of the mam-
mary apparatus in the mouse,
83.
Aneurysmal dilatations, 123.
Angioma, 29, 70.

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Animals, young, more suitable for

propagation of cancer, 265.
Anomalies in savage races, develop-
mental, 3.

Auti-bodies in the serum, presence
of, 361.

Anus, epithelioma of, in a female
Papuan, 40.

Apolant, 70, 76, 77, 86, 104, 108,
113, 115, 118, 122, 123, 124,
125, 127, 129, 144, 173, 174,
179, 180, 230, 254, 271, 375.
Appearance of halos in mixed
tumours, 196.

Appearances of degeneration, histo-
logical, 302.

of grafts, naked-eye, 343.

Ara macao, 45.

Areas, light and dark, in Jensen's
tumour, 303.

Arsenic cancer, 22.

Artery, emboli in the pulmonary, 70,

91 96, 100.

Artificial purification of mixed

tumours, attempts at, 206.
Association between histological
structure and the resistance of
the animals, 174.

of chronic irritation with the
development of cancer, 19, 24.
of keratinised and adenomatous
areas, 164.

Asymmetrical mitosis, 63, 66.
Atreptic immunity, 136, 141, 142,

319, 386.

Atrophic changes of carcinomatous

alveoli in sclerotic tissue, 213.
Attempts at artificial purification of

mixed tumours, 206.

Australia, Central, 27.

Avidity for food material, differential,

108, 111, 112, 116.

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