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Degenerative changes, signs of eirenlatory disturbances, 123, 200, 424.

Delicate stroma in hæmorrhagic tumours, 129.

Dermoid cysts in birds, 45. Destructive growth, 130, 131. Development of sarcoma, 24, 175, 259. Developmental anomalies in savage

races, 3.

Diagnosing internal cancer, difficulty of, 17.

Diaphragm and gut-wall, infiltrative growth in the, 70.

Differences in the incidence of cancer

in Europe, 3.

in the number of cases recorded in various races, 3.

in the recorded incidence of cancer outside Europe, 10.

in the size of the chromosomes, 64.

Differential avidity for food material, 111, 112.

Differentiated condition, reversion to the, 173.

Difficulties of distinguishing carcino

matous and sarcomatous tissue, 196, 230, 254.

of primary transplantation, 269, 270, 310.

Digestion in mice, usual period of,

400.

Diminution of hydrochloric acid in

malignant disease, 401. Discrepancies between hospital sta

tistics and mortality returns, 18. between hospital statistics in England and India, 18.

between the result of inoculating large and small doses, 275, 325, 364.

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Early stages, degenerative changes

in, 239.

glycogen in, 423.

of hæmorrhagic tumours, 352. of Jensen's tumour in resistant mice, 35.

of mixed tumours, 191, 200, 224, 228, 233.

of sarcoma, 204.

of spontaneous mixed tumours, 253.

of tumour 27 in normal mice, 347, 348.

of tumour 27 in normal rats, 333.

of tumour 27 in resistant mice, 349, 350.

of tumour 27 in resistant rats, 354.

of tumour 32, 160.

of tumour 32 in normal and resistant mice, 352.

of tumour 37, 189, 238.

of tumour 50 in normal mice. 351.

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site of inoculation of, 343.

technique employed in making, 342, 343.

Eberth, 47, 49, 70, 77, 126. Echinoderm eggs, effects of acids and

alkalies on developing, 57. Edlestone, Mr. R. C. S., 45. Effect of a tumour on a normal organism, 433.

of cancer on weight, 103.

of concomitant immunization, 276.

Egg-tubes, Pflüger's, 125.

Egypt, frequency of cancer in, 12.
Ehrenreich, 45.

Ehrlich, 76, 78, 104, 108, 112, 115,

116, 120, 136, 141, 142, 144,

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-skin as an immunizer, 376.

Embryonic rests, 24.

-tissues, immunity from injection of, 376.

Encephaloid cancer of the tibia of a
Papuan, 31.

Endemic foci of cancer, 2.
Enderlen, 241, 242.

Endothelial elements and development of sarcoma, 191. Endotheliomata, 88.

Energy of growth, adaptability in relation to, 113.

of growth, alternating phases of increased and diminished, 279, 300, 324. Engine-drivers, squamous-celled carcinoma of the shin in, 22. England and India, discrepancies between hospital statistics in, 18.

and Wales, Reports of the Registrar-General for, 9.

English mice, Jensen's tumour in, 273.

Ensor, Capt., 12.

Enumerations of chromosomes, 57. Epidemic occurrence of malignant new growths, 2, 3.

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Food material, differential avidity

for, 111, 112. -stuffs, heightened avidity to, 116.

Foot in a Papuan, melanotic sarcoma of the dorsum of the, 40. Fowls, adeno-carcinomata of the small intestine in, 45.

round-celled sarcoma of the intestine in, 45. Fraser, T. R., xxii.

Frequency of cancer in Egypt, 12.

of cancer in India, 12.

of cancer in Japan, 10.

of cancer of the penis, associated with chronic irritation, 19.

of metastasis in inoculated cancer, 265.

of recurrence, 103.

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