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Skin-glands in T. cristatus, carci

noma of the, 50.

-injection, time of development of resistance after, 345.

of animals, carcinoma of the. 41.

of the frog, carcinoma of the, 48.

of the frog, multiple adenomata of the, 47.

Small dose positives, re-inoculation of, 390.

Smallwood, 47, 48.

Smith, Mr. G. Bellingham, 39.
Sobotta, 57.

Solomon islander, 31.

Somatic mitoses, 61.

Specific influence on the connective tissue, 128.

nature of protection, 136, 319, 320, 365, 368, 369.

stroma reaction, 128, 129, 130, 239, 339, 352.

Specificity of protection after injection

of blood, 369.

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absorption, sarcoma development and, 256.

and experimental carcinoma of intestine, 265.

CANCER IN THE MOUSE; histology, metastasis, transplantability,

and the relations of malignant new growths to spontaneously affected animals, 69.

cancer, transplantation into mice with, 109, 110, 321, 322. growth of the small intestine of the mouse, 219.

of the

mammary tumours mouse, table of, 91. mixed tumours, early stages of, 253.

mouse tumours, clinical course of, 91.

mouse tumours, metastasis of, 91.

mouse tumours, results of transplantation of, 91, 104. transplantable sarcoma of the mouse, 202, 249.

tumours, development of in resistant mice, 397.

tumours, metastases of, 97. tumours of the mouse, site of origin, 84.

Spontaneously affected animals, relations of malignant new growths to, 107.

Sporadic tumours, heterogeneity of growth in, 298.

Spriggs and Pembrey, 428, 430, 431,

Spude, 76.

Squamous-cell carcinoma in Gaster

osteus spinachia, 53.

carcinoma of axilla, 81. carcinoma of the neck, 81. carcinoma of the stomach, 71. Squamous-celled carcinoma, 55, 70. carcinoma growing as an adenocarcinoma, 171.

carcinoma, interference with blood-supply of a, 155.

carcinoma of jaw, lymphatic metastases in, 97. carcinoma of nipple, 82. carcinoma of the caruncula of the eye in cattle, 42.

carcinoma of the cervix uteri in a gazelle, 42.

CARCINOMA OF THE MOUSE, TRANSPLANTABLE, 159.

carcinoma of the shin in enginedrivers, 22.

carcinoma, zoological distribution of, 159.

Starling, 356.

Statistics, hospital,

discrepancies

between and mortality returns, 18.

-, hospital, discrepancies between in England and India, 13. value of accurate, 23. Sticker, A., 42, 80, 182. Stirling, 27.

Stomach contents, analysis of, man, table XIV., 418, 419.

contents, analysis of, mice, tables I.-XI. and XIII., 409– 419.

contents, analysis, of, rats, table XII., 415.

squamous-cell carcinoma of the, 71.

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degenerations of the, 122. elements, degenerative changes of the introduced, 190, 348. elements, transplantability of individual, 239, 242, 253, 255.

hæmorrhagic and oedematous changes in the, 87, 123.

in hæmorrhagic tumours, delicate, 129.

of carcinomatous strains of tumour 37, changes in the, 210.

of Jensen's tumour, transitory changes in the, 187.

reaction, angioplastic, fibroblastic, 129, 355.

reaction, failure in resistant animals of, 355.

reaction, specific, 128, 129, 130, 239.

-transplantable from the primary

growth, 252.

Structure and biological behaviour, inter-relations between, 126. and rate of growth, relation between, 125.

and the resistance of the animals, association between histological, 174.

of a lymphatic glandular metastasis in hæmorrhagic spontaneous tumour 25, adenomatous, 131.

of the parenchyma, acinous, 187.

Subdivision of parenchyma during

propagation, 287, 288. Subsequent inoculation, protection against, 319.

Success, fluctuations in percentage of, 272, 289, 305. -in transplantation, 287.

in tumour 27, percentage of, 346.

maximal percentage of, 326. of primary transplantation, 321.

table of percentages of, 306307.

Successes, rate of growth varies with

the percentage of, 346.

Sudan, cancer in, 14.

carcinoma of breast in, 12. Suitability for growth, heightened,

141.

for transplantation of spontaneously affected animals, 321, 322.

of young mice for transplantation, 325.

Summary of sarcoma development, 248.

of tumour 37/9 B, 238. Suppression of carcinoma by sarcoma, 258.

of chemiotactic power, 356.

Surgical interference with blood.

supply of transplanted tumours, 146.

Survival of reaction-tissue, 257. Susceptibility of mice, natural, 324.

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Synapsis, 62.

Syringe, graduated, 119 193, 268.

Table of spontaneous mammary tumours of the mouse, 91.

of the percentages of success, 306-307.

Takaki, 11.

Tatham, 7, 9.

Teacher, J. H., 333.

Technique employed in making early

stages, 342, 343.

for rapid examination of tumours, 185.

of heat experiments, 207.

of operations on mice, 101, 149.

of propagation, 193, 267, 268. Temporary fluctuations of growth,

277.

retardation of growth, 277. Test meals, 401.

Testis, cystic carcinoma of the, 47. protection with, 376.

Thigh, infiltration of the muscles of the, 79.

Thorel, 397.

Thursday Island, 31.

Thyroid enlargement progressing to

the development of true carcinoma in trout, 52.

gland tumours, 126.

in a jackal, sarcoma of the, 42.

in a macaw, carcinoma of the,

45.

in an opossum, carcinoma of the, 42.

tumour of the trout, infectivity of, 52.

Tibia, encephaloid cancer of the, of a Papuan, 31.

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Transplanted tumours, genealogical

tree of, 289.

tumours, inconstancy of the morphological characters of,

188.

tumours, increase of hydrochloric acid in mice with, 400. tumours of strain 32, histology of the, 163.

tumours, vascular supply of, 148.

Tree of transplantations descended from spontaneous tumour 37, genealogical, 211, 260.

of transplanted tumours, genealogical, 289.

Treponema pallidum, 23.

Triton cristatus, carcinoma of the skin-glands in, 50.

Trotter, Mr. A. M., 42.

Trout, infectivity of thyroid tumour

of the, 52.

Tumour, Brooklyn, 281.

cells, adaptability of the, 108. cells, alternating changes in, 276, 278.

I cells as indicators of susceptibility, 324.

cells during propagation, adaptability and biological alterations of, 269, 280.

cells, energy of growth of, 324.

development, belated, 135. effect of, on a normal organism, 433.

50 in normal mice, early stages of, 351.

fluctuations in growth of Jensen's, 294.

hæmorrhagic, spontaneous absorption in, 332.

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