Full No. 211. VOL. XIX. No. 1. JULY, 1899. Denver Medical Times THOMAS HAYDEN HAWKINS, M.D., LL.D., EDITOR. We Test Them Physiologically ERGOT, CANNABIS INDICA, DIGITALIS, STROPHANTHUS, and other toxic and narcotic drugs. If you want a reliable fluid extract of these drugs that is submitted to a careful physiological test before it leaves the laboratory, specify P., D. & Co., and you will get it. ONE REASON WHY YOU SHOULD SPECIFY P., D. & CO. Over 30,000 pounds of Cannabis Indica and 20,000 pounds of Ergot were rejected by us during the past twelve months-condemned by our Pharmacological Laboratory on the cogent ground of defective activity, or complete inertness. REJECTED BY US, WHAT BECAME OF THEM? The only possible means of trustworthy assay of many powerful drugs is a physiological test, and we make it in our Pharmacological Laboratory. PARKE, DAVIS & COMPANY, HOME OFFICES AND LABORATORIES, DETROIT, MICHIGAN. BRANCHES IN NEW YORK, KANSAS CITY, BALTIMORE AND NEW ORLEANS. ARTIFICIAL LEGS Largest Firm in U. S. Send for 1899 Catalogue. THE WINKLEY CONTENTS. The Medical Efficacy of Nosophen and Antinosine in Eye, Ear, Nose and Throat Affections, by James A. Lydston, M.D., Chicago, Illinois A Plea for Psychical Realism, by James Weir, Jr., M.D., Owensboro, Kentucky.. McK. & R. Is the most satisfactory dusting powder for almost all purposes. It does not Compound Stearate of Zinc with Ichthyol (McK. & R.) Ichthyol is of undoubted value in many forms of skin disease. In some cases it We shall be pleased to send samples of this or any other combination, together with McKesson & Robbins, New York. 5529 LIBRARY DENVER MEDICAL TIMES VOLUME XIX. JULY, 1899. NUMBER 1. ORIGINAL COMMUNICATIONS. THE MEDICAL EFFICACY OF NOSOPHEN AND ANTINOSINE By JAMES A. LYDSTON, M.D., Ph.G., Ophthalmologist and Otologist to St. Joseph's Hospital; Late Chief of the Eye and Ear Chicago, Illinois. So great is the multiplicity of indifferent therapeutical agents thrust upon the medical fraternity at the present time that we should rejoice over the presentation of any chemical agent that is really entitled to a place in our therapeutical armamentarium by virtue of true merit. Among the many products that have been extolled in recent years as possessing su perior germicidal and antiseptic qualities are two chemical compounds, viz., nosophen and antinosine, the first being chemically, as described by Classen and Loeb, tetra iodophnolphthalein, and the latter the sodium salt of the same. Nosophen being a light impalpable yellowish gray, practically odorless, tasteless powder, very stable, requiring a temperature of 220 C. for decomposition, containing 61.7 per cent. of iodine in combination resulting from chemical reaction between iodine and phenolphthalein solutions, characterized by being insoluble in water and acids, soluble with difficulty in alcohol, glacial acetic acid, chloroform and ether, and readily soluble in alkaline solutions, from which it is readily separable at low temperature by carbonic acid-acid in character, containing as it does two hydroxyl groups, it is freely soluble in alkalies, the hydrogen in both hydroxyl groups being replaced by the metal. The sodium salt thus obtained has been isolated and is styled antinosine-this compound, the sodium salt of nosophen, is a dark blue amorphous, odorless, non-toxic, non-irritating * Read before Chicago Medical Society, May 24, 1899. |